Maternal intrapartum antibiotics and decreased vertical transmission of Lactobacillus to neonates during birth.
Acta Paediatr. 2013 Feb 7. Epub 2013 Feb 7. PMID: 23398392
Department of Obstetrics and Gynaecology, Kuopio University Hospital; Department of Environmental Health, National Institute for Health and Welfare, Kuopio, Finland.
AIM: To estimate transmission of maternal vaginal microbiota to neonates during term delivery, focusing on Lactobacillus flora in relation to various obstetric clinical factors. METHODS: 50 consecutive pregnant healthy women with singleton term pregnancies and their newborn infants. Vertical transmission of Lactobacillus flora to newborn during delivery was evaluated in 45 mother-newborn pairs. RESULTS: Lactobacillus-dominant mixed flora was detected in 90% (N=45) of vaginal samples, but only in 28% (N=14) of neonatal cultures (transmission rate 31%). All neonates with Lactobacillus-dominant mixed flora had findings similar to those in maternal cultures. Cocci-dominant flora was the most common finding in neonates. Administration of antibiotics to the mother during the intrapartum period before birth and duration of rupture of membranes (ROM), regardless of maternal antibiotic treatment, were associated significantly with a decreased transmission rate of Lactobacillus-dominant flora to neonates. CONCLUSION: Maternal intrapartum antibiotics and prolonged expectant management after ROM was associated with decreased transmission rate of vaginal Lactobacillus flora to the neonate during birth. Since early colonization of Lactobacillus flora may have a preventive role in the development of allergic diseases later, the significance of intrapartum prophylactic antibiotics needs to be highlighted in forthcoming studies, especially as regards immunological development of the offspring.©2013 The Author(s)/Acta Paediatrica ©2013 Foundation Acta Paediatrica.