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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Matricaria chamomilla extract inhibits both development of morphine dependence and expression of abstinence syndrome in rats.

Abstract Source:

J Pharmacol Sci. 2003 May;92(1):50-5. PMID: 12832855

Abstract Author(s):

Adel Gomaa, Tahia Hashem, Mahmoud Mohamed, Esraa Ashry

Abstract:

The effect of Matricaria chamomilla (M. chamomilla) on the development of morphine dependence and expression of abstinence was investigated in rats. The frequencies of withdrawal behavioral signs (paw tremor, rearing, teeth chattering, body shakes, ptosis, diarrhea, and urination) and weight loss induced by naloxone challenge were demonstrated in morphine-dependent rats receiving M. chamomilla extract or saline. The withdrawal behavioral manifestations and weight loss were inhibited significantly by chronic co-administration of M. chamomilla extract with morphine. Administration of a single dose of M. chamomilla before the naloxone challenge in morphine-dependent animals abolished the withdrawal behavioral manifestations. The dramatic increase of plasma cAMP induced by naloxone-precipitated abstinence was prevented by chronic co-administration of M. chamomilla extract with morphine. These results suggest that M. chamomilla extract inhibits the development of morphine dependence and expression of abstinence syndrome.


Study Type : Animal Study

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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