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Abstract Title:

Local anaesthetic, antibacterial and antifungal properties of sesquiterpenes from myrrh.

Abstract Source:

Planta Med. 2000 May;66(4):356-8. PMID: 10865454

Abstract Author(s):

P Dolara, B Corte, C Ghelardini, A M Pugliese, E Cerbai, S Menichetti, A Lo Nostro

Abstract:

We extracted, purified and characterized 8 sesquiterpene fractions from Commyphora molmol. In particular, we focused our attention on a mixture of furanodiene-6-one and methoxyfuranoguaia-9-ene-8-one, which showed antibacterial and antifungal activity against standard pathogenic strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans, with minimum inhibitory concentrations ranging from 0.18 to 2.8 micrograms/ml. These compounds also had local anaesthetic activity, blocking the inward sodium current of excitable mammalian membranes.

Study Type : In Vitro Study

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