Abstract Title:

n-3 Polyunsaturated fatty acids protect against pancreaticβ-cell damage due to ER stress and prevent diabetes development.

Abstract Source:

Mol Nutr Food Res. 2015 Jun 15. Epub 2015 Jun 15. PMID: 26080997

Abstract Author(s):

Jie Wang, Mi-Young Song, Ui-Jin Bae, Jung Min Lim, Keun Sang Kwon, Byung-Hyun Park

Article Affiliation:

Jie Wang

Abstract:

SCOPE: In this study, we focus on the effects of n-3 polyunsaturated fatty acids (PUFAs) on tunicamycin-, streptozotocin-, or high fat diet (HFD)-inducedβ-cell damage and dysfunction.

MATERIALS AND METHODS: Pretreatment with n-3 PUFAs protected RINm5F cells and mouse islets against tunicamycin-inducedβ-cell damage through suppression of ER stress and apoptosis induction. This protective effect of n-3 PUFAs on β-cells was further demonstrated by the normalization of insulin secretion in response to glucose in tunicamycin-treated islets. In multiple low-dose streptozotocin-induced diabetes models, fat-1 mice, which endogenously synthesize n-3 PUFAs from n-6 PUFAs, were fully resistant to the development of diabetes, with normal islet morphology, high insulin immunoreactivity, and decreased apoptotic cells. In HFD-induced diabetes models, fat-1 mice also exhibited improved glucose toleranceand functional β-cell mass. In both diabetes models, we observed an attenuation of ER stress in fat-1 mice. Interestingly, n-3 PUFAs attenuated the nuclear translocation of lipogenic transcription factors sterol regulatory element-binding protein-1 (SREBP-1) and C/EBPβ, induced by tunicamycin orHFD, suggesting that n-3 PUFAs suppress ER stress via modulation of SREBP-1 and C/EBPβ.

CONCLUSION: Together, these results suggest that n-3 PUFAs block ER stress, thus protectingβ cells against diabetogenic insult; therefore, dietary supplementation of n-3 PUFAs has therapeutic potential for the preservation of functional β-cell mass.

Study Type : Animal Study

Print Options


This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.