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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Protective Role Of Naringenin Against Aβ-Caused Damage via ER and PI3K/Akt-Mediated Pathways.

Abstract Source:

Cell Mol Neurobiol. 2018 Mar ;38(2):549-557. Epub 2017 Jul 11. PMID: 28699113

Abstract Author(s):

Ning Zhang, Zhonghua Hu, Zhibo Zhang, Guoliang Liu, Yeqiu Wang, Yandong Ren, Xiuhong Wu, Fang Geng

Article Affiliation:

Ning Zhang

Abstract:

Senile plaque accumulation and neurofibrillary tangles are primary characteristics of Alzheimer's disease. We aimed to assess the protective functions of naringenin againstβ-amyloid protein fragment 25-35 (Aβ)-caused nerve damage in differentiated PC12 cells, and study the potential mechanisms. We evaluated cell viability and apoptosis using the 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) test and flow cytometry, respectively. Moreover, we measured protein kinase B (Akt), glycogen synthase kinase-3β (GSK-3β), and caspase-3 activity via western blotting and RT-PCR. We found that naringenin protected cell against Aβ-caused nerve damage by increasing cell viability, promoting Akt and GSK3β activation, and inhibiting cell apoptosis and caspase-3 activity. However, treatment with the estrogen receptor (ER) antagonist ICI182, 780 or phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 suppressed the effects of naringenin. Our results suggested that naringenin could effectively suppress Aβ-caused nerve damage in PC12 cells by regulating the ER and PI3K/Akt pathways.

Study Type : In Vitro Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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