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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

The beneficial effects of nettle supplementation and exercise on brain lesion and memory in rat.

Abstract Source:

J Nutr Biochem. 2008 Dec 12. PMID: 19071007

Abstract Author(s):

Anna Toldy, Mustafa Atalay, Krisztián Stadler, Mária Sasvári, Judit Jakus, Kyung J Jung, Hae Y Chung, Csaba Nyakas, Zsolt Radák

Abstract:

Regular swimming and phytotherapeutic supplementation are assumed to alleviate the severity of neurodegeneration leading to dementia. The effect of swimming training and that of enriched lab chow containing 1% (w/w) dried nettle (Urtica dioica) leaf on the prevention of severity of brain injury caused by N-methyl-d-aspartate (NMDA) lesion in Wistar rats were investigated. Nettle supplementation and regular swimming exercise seem to improve the adverse effect of brain injury caused by NMDA lesion assessed by passive avoidance test and open-field test. Nettle supplementation decreases the level of reactive oxygen species, measured by electron paramagnetic resonance, and the DNA-binding activity of NF-kappaB. The data reveal that nettle supplementation has an effective antioxidant role, down-regulates the inflammatory transcription factors and could also promote learning performance in the brain. Regular swimming increases the concentration of reactive species in the cerebellum and alters the activity of transcription factors toward inflammation. The additive effect of the two treatments was more profound in the down-regulation of inflammatory transcription processes in NMDA lesion.

Study Type : Animal Study

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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