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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Oral administration of Nigella sativa oil ameliorates the effect of cisplatin on brush border membrane enzymes, carbohydrate metabolism and antioxidant system in rat intestine.

Abstract Source:

Exp Toxicol Pathol. 2017 Feb 15. Epub 2017 Feb 15. PMID: 28215571

Abstract Author(s):

Faaiza Shahid, Zeba Farooqui, Sana Rizwan, Subuhi Abidi, Iqbal Parwez, Farah Khan

Article Affiliation:

Faaiza Shahid

Abstract:

Cisplatin (CP) is an effective chemotherapeutic agent that induces gastrointestinal toxicity. Nigella sativa oil (NSO) has been shown to be beneficial in a wide range of gastrointestinal disorders. The present study investigates the possible protective effect of NSO on CP-induced gastrointestinal toxicity. NSO administration (2ml/kg bwt, orally), prior to and following, a single dose CP treatment (6mg/kg bwt. ip), significantly attenuated the CP-induced decrease in brush border membrane (BBM) enzyme activities in intestinal homogenates and BBM vesicles (BBMV). NSO administration also mitigated CP induced alterations in the activities of carbohydrate metabolism enzymes and in the enzymatic and non-enzymatic antioxidant parameters in the intestine. The results suggest that NSO by empowering the endogenous antioxidant system improves intestinal redox and metabolic status and restores BBM integrity in CP treated rats. Histopathological studies supported the biochemical findings. Thus, NSO may help prevent the accompanying gastrointestinal dysfunction in CP chemotherapy.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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