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Abstract Title:

Radiation-modifying abilities of Nigella sativa and Thymoquinone on radiation-induced nitrosative stress in the brain tissue.

Abstract Source:

Phytomedicine. 2013 Nov 21. pii: S0944-7113(13)00432-7. doi: 10.1016/j.phymed.2013.10.023. [Epub ahead of print]

Abstract Author(s):

Adem Ahlatci, Abdurahman Kuzhan, Seyithan Taysi, Omer Can Demirtas, Hilal Eryigit Alkis, Mehmet Tarakcioglu, Ali Demirci, Derya Caglayan, Edibe Saricicek, Kadir Cinar

Article Affiliation:

Department of Radiation Oncology, Gaziantep University, Medical School, Gaziantep, Turkey.

Abstract:

To investigate Nigella sativa oil (NSO) and Thymoquinone (TQ) for their antioxidant effects on the brain tissue of rats exposed to ionizing radiation. Fifty-four male albino Wistar rats, divided into six groups, were designed as group I (normal control group) did not receive NSO, TQ or irradiation; group II (control group of TQ) received dimethyl sulfoxide and sham irradiation; group III (control group of NSO) received saline and sham irradiation; group IV (irradiation plus NSO group) received both 5 Gray of gamma irradiation to total cranium and NSO; group V (irradiation plus TQ group) received both irradiation and TQ; group VI (irradiation alone group) received irradiation plus saline. Alterations in nitric oxide (NO) and peroxynitrite (ONOO(-)) levels, and nitric oxide synthase (NOS) enzyme activity were measured by biochemical methods in homogenized brain tissue of rats. Levels of NO and ONOO(-), and enzyme activity of NOS in brain tissue of the rats treated with NSO or TQ were found to be lower than in received IR alone (p<0.002) Nigella sativa oil (NSO) and its active component, TQ, clearly protect brain tissue from radiation-induced nitrosative stress.

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Sayer Ji
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