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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Lipoxygenase Inhibitors Nordihydroguaiaretic Acid and Fungus Lecanicillum lecanii Extract Induce Death of Lymphoid Leukemia Cells.

Abstract Source:

Bull Exp Biol Med. 2017 Jul ;163(3):330-333. Epub 2017 Jul 26. PMID: 28744653

Abstract Author(s):

M V Bibikova, N A Spiridonova, A F Korystova, L N Kublik, M Kh Levitman, V V Shaposhnikova, Yu N Korystov

Article Affiliation:

M V Bibikova

Abstract:

We studied the effect of lipoxygenase inhibitors nordihydroguaiaretic acid (NDGA) and fungus Lecanicillum lecanii extract on lymphatic leukemia P388 cells. The cells grown in the abdominal cavity of DBA2 mice for 7 days were transferred into a nutrient medium. The effect of lipoxygenase inhibitors was evaluated by changes in cell number, trypan blue staining, nucleus damage, and changes in cell distribution by DNA content after 22-h incubation. NDGA and fungus extract induced apoptotic death of lymphatic leukemia cells, which was seen from nucleus damage and reduced DNA content in cells. ICfor NDGA and fungus extract was 0.66 and 5.5μg/ml, respectively.

Study Type : In Vitro Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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