Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Chemosensitization and radiosensitization of tumors by plant polyphenols.

Abstract Source:

Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1630-47. PMID: 16356126

Abstract Author(s):

Amit K Garg, Thomas A Buchholz, Bharat B Aggarwal

Article Affiliation:

Department of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

Abstract:

The treatment of cancer with chemotherapeutic agents and radiation has two major problems: time-dependent development of tumor resistance to therapy (chemoresistance and radioresistance) and nonspecific toxicity toward normal cells. Many plant-derived polyphenols have been studied intently for their potential chemopreventive properties and are pharmacologically safe. These compounds include genistein, curcumin, resveratrol, silymarin, caffeic acid phenethyl ester, flavopiridol, emodin, green tea polyphenols, piperine, oleandrin, ursolic acid, and betulinic acid. Recent research has suggested that these plant polyphenols might be used to sensitize tumor cells to chemotherapeutic agents and radiation therapy by inhibiting pathways that lead to treatment resistance. These agents have also been found to be protective from therapy-associated toxicities. How these polyphenols protect normal cells and sensitize tumor cells to treatment is discussed in this review.

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Sayer Ji
Founder of GreenMedInfo.com

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Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

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