One stressful event blocks multiple actions of diazepam for up to at least a month. - GreenMedInfo Summary
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Abstract Title:
One stressful event blocks multiple actions of diazepam for up to at least a month.
Abstract Source:
Brain Res. 1988 Apr 5 ;445(2):380-5. PMID: 3370472
Article Affiliation:
S M Antelman
Abstract:
Based on recent findings of this laboratory, the hypothesis was tested that a single stressful encounter might have a persistent antidiazepam influence. Our results indicate that one exposure to a brief stressful event up to at least one month earlier prevented completely the effect of diazepam on pentylenetetrazole-induced changes in dopamine in the rat frontal cortex, elevations of plasma corticosterone levels and seizures.
Article Published Date : Apr 04, 1988
Study Type : Animal Study
Additional Links
Diseases : Anxiety : CK(3958) : AC(691), Psychological Distress : CK(65) : AC(9), Stress : CK(1029) : AC(194)
Problem Substances : Benzodiazepines : CK(184) : AC(19)
