Oolong tea polyphenol extract induces programmed cell death in human stomach cancer cells. - GreenMedInfo Summary
Abstract Title:
Oolong tea polyphenol extract induces apoptosis in human stomach cancer cells.
Abstract Source:
Anticancer Res. 2000 Nov-Dec;20(6B):4403-6. PMID: 11205279
Abstract:
The exposure of human stomach cancer KATO III cells to oolong tea polyphenol extact [OTPE] containing oolong tea polyphenol trimer [OTP trimer] as a main component, led to both growth inhibition and the induction of apoptosis. Morphological change showing apoptotic bodies was observed in the cells treated with OTPE. The fragmentation by OTPE of DNA to oligonucleosomalsized fragments that are characteristics of apoptosis was observed to be concentration- and time-dependent. These data suggest that the growth inhibition by OTPE results from the induction of apoptosis in the KATO III cells.
Article Published Date : Nov 01, 2000
Study Type : In Vitro Study
Additional Links
Substances : Oolong tea : CK(56) : AC(18)
Diseases : Stomach Cancer : CK(1167) : AC(689)
Pharmacological Actions : Apoptotic : CK(6986) : AC(6931)
