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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Dammarane-type triterpene extracts of Panax notoginseng root ameliorates hyperglycemia and insulin sensitivity by enhancing glucose uptake in skeletal muscle.

Abstract Source:

Biosci Biotechnol Biochem. 2016 Oct 24:1-8. Epub 2016 Aug 24. PMID: 27771987

Abstract Author(s):

Kumiko Kitamura, Yusuke Takamura, Taku Iwamoto, Mitsuru Nomura, Hideaki Iwasaki, Motoyasu Ohdera, Michiaki Murakoshi, Keikichi Sugiyama, Kazuki Matsuyama, Yasuko Manabe, Nobuharu L Fujii, Tohru Fushiki

Article Affiliation:

Kumiko Kitamura

Abstract:

Skeletal muscle is an important organ for controlling the development of type 2 diabetes. We discovered Panax notoginseng roots as a candidate to improve hyperglycemia through in vitro muscle cells screening test. Saponins are considered as the active ingredients of ginseng. However, in the body, saponins are converted to dammarane-type triterpenes, which may account for the anti-hyperglycemic activity. We developed a method for producing a dammarane-type triterpene extract (DTE) from Panax notoginseng roots and investigated the extract's potential anti-hyperglycemic activity. We found that DTE had stronger suppressive activity on blood glucose levels than the saponin extract (SE) did in KK-A(y) mice. Additionally, DTE improved oral glucose tolerance, insulin sensitivity, glucose uptake, and Akt phosphorylation in skeletal muscle. These results suggest that DTE is a promising agent for controlling hyperglycemia by enhancing glucose uptake in skeletal muscle.

Study Type : Animal Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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