Patients taking aspirin plus ibuprofen have an increased risk of all-cause mortality. - GreenMedInfo Summary
Effect of ibuprofen on cardioprotective effect of aspirin.
Lancet. 2003 Feb 15;361(9357):573-4. PMID: 12598144
Medicines Monitoring Unit, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, DD1 9SY, Dundee, UK. firstname.lastname@example.org
Treatment with ibuprofen might limit the cardioprotective effects of aspirin. We aimed to assess whether patients with known cardiovascular disease who take low-dose aspirin and ibuprofen have increased risk of cardiovascular mortality. We studied 7107 patients who were discharged after first admission for cardiovascular disease between April, 1989, and April, 1997, and who were prescribed low-dose aspirin (<325 mg>