Abstract Title:

Perinatal exposure to bisphenol A modifies the transcriptional regulation of theβ-Casein gene during secretory activation of the rat mammary gland.

Abstract Source:

Mol Cell Endocrinol. 2016 Sep 30. Epub 2016 Aug 30. PMID: 27697584

Abstract Author(s):

Gabriela A Altamirano, Jorge G Ramos, Ayelen L Gomez, Enrique H Luque, Monica Muñoz-de-Toro, Laura Kass

Article Affiliation:

Gabriela A Altamirano

Abstract:

With the aim to analyze whether bisphenol A (BPA) modifiesβ-Casein (β-Cas) synthesis and transcriptional regulation in perinatally exposed animals, here, pregnant F0 rats were orally exposed to 0, 0.6 or 52 μg BPA/kg/day from gestation day 9 until weaning. Then, F1 females were bred and mammary glands were obtained on lactation day 2. Perinatal BPA exposure decreased β-Cas expression without modifying the activation of prolactin receptor. It also decreased the expression of glucocorticoid receptor in BPA52-exposed dams and β1 and α6 integrins as well as dystroglycan in both BPA groups. In addition, BPA exposure altered the expression of histone-modifying enzymes and induced histone modifications and DNA methylation in the promoter, enhancer and exon VII of the β-Cas gene. An impaired crosstalk between the extracellular matrix and lactogenic hormone signaling pathways and epigenetic modifications of the β-Cas gene could be the molecularmechanisms by which BPA decreased β-Cas expression.

Study Type : Animal Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.