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Abstract Title:

Phenolic compounds isolated from Morus nigra and theirα-glucosidase inhibitory activities.

Abstract Source:

Nat Prod Res. 2018 Oct 27:1-8. Epub 2018 Oct 27. PMID: 30369248

Abstract Author(s):

Liangjin Xu, Meihua Yu, Lixin Niu, Chunyue Huang, Yifan Wang, Chunzhen Wu, Peiming Yang, Xiao Hu

Article Affiliation:

Liangjin Xu

Abstract:

A novel benzofuranone unprecedentedly with a prenyl group at C-3, nigranol A (1), a new flavonol, nigranol B (2), and three known compounds, sanggenon M (3), nigrasin C (4), and nigrasin A (5) were isolated from the twigs of Morus nigra Linn. Their structures were elucidated on the basis of the analysis of multiple spectroscopic data. All of the compounds, along with eight previously isolated ones (6-13) were investigated for theirα-glucosidase inhibitory activities. The result showed that compounds 1-13 except 4 exhibited prominent inhibitory activities against α-glucosidase. Among them, compounds 2 and 7 were the best α-glucosidase inhibitory candidates with ICvalues at 1.63 and 1.43 μM, respectively. Furthermore, the structure-activity relationships of the sanggenon-type flavanones were summarized. [Formula: see text].

Study Type : In Vitro Study

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