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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Phloretin promotes adipocyte differentiation in vitro and improves glucose homeostasis in vivo.

Abstract Source:

J Nutr Biochem. 2014 Dec ;25(12):1296-308. Epub 2014 Sep 16. PMID: 25283330

Abstract Author(s):

Gang Shu, Nai-Sheng Lu, Xiao-Tong Zhu, Yong Xu, Min-Qing Du, Qiu-Ping Xie, Can-Jun Zhu, Qi Xu, Song-Bo Wang, Li-Na Wang, Ping Gao, Qian-Yun Xi, Yong-Liang Zhang, Qing-Yan Jiang

Article Affiliation:

Gang Shu

Abstract:

Adipocyte dysfunction is associated with many metabolic diseases such as obesity, insulin resistance and diabetes. Previous studies found that phloretin promotes 3T3-L1 cells differentiation, but the underlying mechanisms for phloretin's effects on adipogenesis remain unclear. In this study, we demonstrated that phloretin enhanced the lipid accumulation in porcine primary adipocytes in a time-dependent manner. Furthermore, phloretin increased the utilization of glucose and nonesterified fatty acid, while it decreased the lactate output. Microarray analysis revealed that genes associated with peroxisome proliferator-activated receptor-γ (PPARγ), mitogen-activated protein kinase and insulin signaling pathways were altered in response to phloretin. We further confirmed that phloretin enhanced expression of PPARγ, CAAT enhancer binding protein-α (C/EBPα) and adipose-related genes, such as fatty acids translocase and fatty acidsynthase. In addition, phloretin activated the Akt (Thr308) and extracellular signal-regulated kinase, and therefore, inactivated Akt targets protein. Wortmannin effectively blocked the effect of phloretin on Akt activity and the protein levels of PPARγ, C/EBPα and fatty acid binding protein-4 (FABP4/aP2). Oral administration of 5 or 10 mg/kg phloretin to C57BL BKS-DB mice significantly decreased the serum glucose level and improved glucose tolerance. In conclusion, phloretin promotes the adipogenesis of porcine primary preadipocytes through Akt-associated signaling pathway. These findings suggested that phloretin might be able to increase insulin sensitivity and alleviate the metabolic diseases.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Insulin Sensitizers : CK(350) : AC(70)
Problem Substances : Insulin : CK(149) : AC(23)

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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