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Depression: 21st Century Solutions + The Dark Side of Wheat

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Article Publish Status: FREE
Abstract Title:

Polysaccharide peptide isolated from grass-culturedinduces anti-proliferative and pro-apoptotic effects in the human U251 glioma cell line.

Abstract Source:

Oncol Lett. 2018 Apr ;15(4):4330-4336. Epub 2018 Jan 19. PMID: 29541200

Abstract Author(s):

Chunhua Wang, Dongmei Lin, Quan Chen, Shuqian Lin, Songsheng Shi, Chunmei Chen

Article Affiliation:

Chunhua Wang

Abstract:

The() mushroom is one of the most extensively studied functional foods, known for its numerous health benefits, including the inhibition of tumor cell growth. The present study assessed the anti-proliferative and pro-apoptotic activity of a novelpolysaccharide peptide (GL-PP) in human glioma U251 cells, which was purified from grass-cultured. GL-PP is a glycopeptide with an average molecular weight of 42,635 Da and a polysaccharide-to-peptide ratio of 88.70:11.30. The polysaccharides were composed of l-arabinose, d-mannose and d-glucose at a molar ratio of 1.329:0.372:2.953 and a total of 17 amino acids were detected. The results of the current study demonstrated that GL-PP significantly inhibited U251 cellular proliferation. The proportion of G/Gphase cells and sub-Gphase cells significantly increased as the concentration of GL-PP increased, as did the activity of caspase-3. These results indicate that GL-PP directly inhibited human glioma U251 proliferation by inducing cell cycle arrest and promoting apoptosis.

Study Type : In Vitro Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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