Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

n/a
Abstract Title:

Antinociceptive and anti-inflammatory effect of Naringenin in different nociceptive and inflammatory mice models.

Abstract Source:

Life Sci. 2018 Nov 7. Epub 2018 Nov 7. PMID: 30414428

Abstract Author(s):

Na Xue, Xianwei Wu, Li Wu, Lu Li, Fang Wang

Article Affiliation:

Na Xue

Abstract:

Inflammation is the vital defensive response triggered by our immune system against an infection or deleterious stimuli. This response in due course affects its own biological system leading to serious diseases like arteriosclerosis, osteoporosis, pancreatitis, cancer etc. Currently, researchers focused on utilizing phytochemicals as anti-inflammatory drugs since the drugs presently available in the market causes serious side effects and are less potent. Flavonoids are polyphenols which imparts colours to the plants and fruits. These flavonoids serve as phytonutrients to plants and they also possess antioxidant, anti-inflammatory and anti-cancer properties. Naringenin is one such flavonoid classified under flavones groups present in citrus fruits and vegetables. The present study is aimed to identify and confirm the antinociceptive and anti-inflammatory efficacy of Naringenin in different mice models. The antinociceptive effect of Naringenin was analyzed by both thermal induced and chemical induced nociceptive mice models. Carrageenan-induced paw edema test was performed to detect the anti-inflammatory effect of Naringenin and it is confirmed by analyzing the leukocyte infiltration in peritoneal cavity. Air pouch model test is performed to estimate the inhibitory property of Naringenin against proinflammatory cytokines. The potency of drug Naringenin was confirmed by treating along with opioid inhibitors naloxone and the results compared with standard drugs. To assess the muscle relaxant property of Naringenin open field test was performed. The overall results of Naringenin in different nociceptive and inflammatory mice models suggest that, Naringenin is a potent anti-inflammatory drug which relieves pain effectively and can be used in pain management therapy.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2018 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.