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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

[Preparation optimization of extract of Moringa oleifera leaves and its immune regulation effect on immunosuppressed mice].

Abstract Source:

Zhongguo Zhong Yao Za Zhi. 2018 Jul ;43(13):2697-2704. PMID: 30111019

Abstract Author(s):

Mao-Lin Huang, Wei-Ming Lin, Xiao-Ling Lin, Ying-Pei Zhang, Wan-Zhen Shi, Ping Xiong

Article Affiliation:

Mao-Lin Huang

Abstract:

With total flavonoid content and dry extract yield as the observation indexes, the optimal extraction conditions of Moringa oleifera leaves were determined by using single factor test and orthogonal test, and cyclophosphamide modeling method was used to establish immunosuppressed mice models, so as to investigate the effects of M. oleifera leaves extract on immune regulation in mice. The results showed that the optimal preparation conditions were as follows: extraction with 70% ethanol, material-liquid ratio 1:15, extraction temperature 80°C, three times, 1.5 hours for each time. Under these conditions, the content of total flavonoids from M. oleifera leaves was 15.64 mg·g⁻¹, which can significantly enhance macrophage phagocytosis and immune organ index, promote the synthesis of serum immunoglobulin IgG and hemolysin, and decrease AST activity, with regulation effect on immune dysfunction.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Immunomodulatory : CK(1287) : AC(358)

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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