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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Association between perfluorooctanoic acid exposure and degranulation of mast cells in allergic inflammation.

Abstract Source:

J Appl Toxicol. 2016 Sep 29. Epub 2016 Sep 29. PMID: 27682001

Abstract Author(s):

Jun-Kyoung Lee, Soyoung Lee, Moon-Chang Baek, Byung-Heon Lee, Hyun-Shik Lee, Taeg Kyu Kwon, Pil-Hoon Park, Tae-Yong Shin, Dongwoo Khang, Sang-Hyun Kim

Article Affiliation:

Jun-Kyoung Lee

Abstract:

Perfluorooctanoic acid (PFOA) has wide applications, including as a raw material for converted paper and packaging products. With the widespread use of PFOA, concerns regarding its potential environmental and health impacts have increased. In spite of the known hepatotoxicity and genotoxicity of PFOA, correlation with PFOA and allergic inflammation is not well known. In this study, the effect of PFOA on the degranulation of mast cells and mast cell-mediated allergic inflammation in the presence of FcεRI cross-linking was evaluated. In immunoglobulin (Ig) E-stimulated mast cells, PFOA increased the release of histamine and β-hexosaminidase by the up-regulation of intracellular calcium levels. PFOA enhanced gene expression of several pro-inflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-8 by the activation of nuclear factor (NF)-κB in IgE-stimulated mast cells. Also, PFOA exacerbated allergic symptoms via hypothermia, and an increase of serum histamine, TNF-α, IgE and IgG1 in the ovalbumin-induced systemic anaphylaxis. The present dataindicate that PFOA aggravated FcɛRI-mediated mast cell degranulation and allergic symptoms. Copyright © 2016 John Wiley&Sons, Ltd.

Study Type : In Vitro Study
Additional Links
Adverse Pharmacological Actions : Inflammatory : CK(298) : AC(83)

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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