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Article Publish Status: FREE
Abstract Title:

Sepsis-induced acute kidney injury: kidney protection effects by antioxidants.

Abstract Source:

Rev Bras Enferm. 2018 Jul-Aug;71(4):1921-1927. PMID: 30156678

Abstract Author(s):

Carolina Ferreira Vasco, Mirian Watanabe, Cassiane Dezoti da Fonseca, Maria de Fátima Fernandes Vattimo

Article Affiliation:

Carolina Ferreira Vasco

Abstract:

OBJECTIVE: To evaluate the antioxidant action of N-acetylcysteine and diosmin-hesperidin in an experimental model of sepsis-induced acute kidney injury in rats.

METHODS: The study used 20 Wistar adult male rats divided into the following groups: control (laparotomy with no induction of abdominal sepsis), sepsis (experimental model of sepsis with cecal ligation and puncture), N-acetylcysteine + sepsis and diosmin-hesperidin + sepsis. The evaluation contemplated physiological parameters (temperature, glycemia, and average blood pressure), kidney function (creatinine clearance), oxidative stress (urinary peroxides) and kidney histology.

RESULTS: The animals submitted to cecal ligation and puncture (sepsis) presented lower body temperature, lower average blood pressure, reduced creatinine clearance and increased urinary hydrogen peroxide levels. Treatment with diosmin-hesperidin improved kidney function and led to a reduction in the excretion of oxidative metabolites.

CONCLUSION: The present study highlighted the protective antioxidant action of diosmin-hesperidin in the experimental model of sepsis-induced acute kidney injury.

Study Type : Animal Study

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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