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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Effect of electronic cigarettes on human middle ear.

Abstract Source:

Int J Pediatr Otorhinolaryngol. 2018 Jun ;109:67-71. Epub 2018 Mar 28. PMID: 29728187

Abstract Author(s):

Jae-Jun Song, Yoon Young Go, Ji Yoen Mun, Sehee Lee, Gi Jung Im, Yoo Yon Kim, Jun Ho Lee, Jiwon Chang

Article Affiliation:

Jae-Jun Song

Abstract:

OBJECTIVE: Electronic cigarettes (e-cigarettes) are the most commonly used electronic nicotine delivery systems and are a relatively new product designed for smoking cessation. The market scale of electronic cigarettes is growing rapidly, but the potential impact of e-cigarettes on public health has not yet been verified. In this study, we examined the effect of e-liquids on a human middle ear epithelial cell (HMEEC) line.

MATERIAL AND METHODS: The main components of e-liquids are propylene glycol, vegetable glycerin and flavoring agents with or without nicotine. We analyzed 73 bottles of e-liquids from 12 different manufacturers, evaluated the trace elements in e-liquids, and identified the cytotoxicity of e-liquids on HMEECs in the presence or absence of nicotine.

RESULTS: In the trace elements analysis, nickel, arsenic, cadmium, and lead were detected in the e-liquids. E-liquids without nicotine decreased cell viability, and the average IC 50 value of total e-liquids (n = 73) was 2.48 ± 0.93%. Among the different flavors, menthol-flavored e-liquids significantly reduced cell viability, and their average IC 50 value (n = 28) was 1.85 ± 0.80%. The average IC 50 values were distinct among manufacturers and the proportion of the solvents.

CONCLUSION: The present study provides evidence that e-cigarettes influence and reduce human middle ear cell viability even without the application of nicotine. Additionally, the cytotoxicity of e-liquids was affected by the flavoring agents.

Study Type : Human In Vitro
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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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