n/a
Abstract Title:

Effects of Probiotics on Non-Alcoholic Fatty Liver Disease in Obese Children and Adolescents: A Randomized Clinical Trial.

Abstract Source:

J Pediatr Gastroenterol Nutr. 2016 Oct 13. Epub 2016 Oct 13. PMID: 27753706

Abstract Author(s):

Fatemeh Famouri, Zainab Shariat, Mahin Hashemipour, Mojtaba Keikha, Roya Kelishadi

Article Affiliation:

Fatemeh Famouri

Abstract:

OBJECTIVES: This trial aims to evaluate the effects of some probiotics on sonographic and biochemical non-alcoholic fatty liver disease (NAFLD).

METHODS: This randomized triple-blind trial was conducted among 64 obese children with sonographic NAFLD. They were randomly allocated to receive probiotic capsule (containing Lactobacillus acidophilus ATCC B3208, 3 × 10 colony forming units, CFU; Bifidobacterium lactis DSMZ 32269, 6 × 10 CFU; B bifidum ATCC SD6576, 2 × 10 CFU; L rhamnosus DSMZ 21690, 2 × 10 CFU) or placebo for 12 weeks.

RESULTS: After intervention, in the probiotic group the mean levels of alanine aminotransferase (ALT) decreased from 32.8 (19.6) to 23.1(9.9) U/L (P = 0.02); and mean aspartate aminotransferase (AST) decreased from 32.2 (15.7) to 24.3 (7.7) U/L (P = 0.02). Likewise the mean cholesterol, LDL-C, and triglycerides, as well as waist circumference decreased in the intervention group, without significant change in weight, BMI, and BMI Z-score. After the trial, normal liver sonography was reported in 17 (53.1%) and 5 (16.5%) of patients in the intervention and placebo groups, respectively.

CONCLUSIONS: The current findings suggest that a course of the abovementioned probiotic compound can be effective in improving pediatric NAFLD.

Study Type : Human Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.