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Article Publish Status: FREE
Abstract Title:

Protective role of puerarin on LPS/D-Gal induced acute liver injury via restoring autophagy.

Abstract Source:

Am J Transl Res. 2018 ;10(3):957-965. Epub 2018 Mar 15. PMID: 29636885

Abstract Author(s):

Long Li, Hongyan Yin, Yan Zhao, Xiaofang Zhang, Chaoli Duan, Jing Liu, Caoxin Huang, Suhuan Liu, Shuyu Yang, Xuejun Li

Article Affiliation:

Long Li

Abstract:

Acute liver injury is a destructive liver disorder resulting from overwhelming liver inflammation, oxidative stress and hepatocyte death. Puerarin is a natural flavonoid compound isolated from the traditional Chinese herb radix puerariae. This study investigated the protective effects of puerarin against lipopolysaccharide (LPS)/D-galactosamine (D-Gal)-induced liver injury and the potential mechanisms in mice. Mice were given an intraperitoneal administration of puerarin 200 mg/kg 2 h prior to LPS (50μg/kg)/D-Gal (400 mg/kg) injection and were sacrificed 6 h post LPS/D-Gal treatment. The results showed that administration of puerarin substantially alleviated LPS/D-Gal-induced acute liver injury in mice by increased survival rates, improved liver histopathology, reduced plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, alleviated production of pro-inflammatory cytokines, and suppressed hepatocyte apoptosis. Moreover, puerarin pretreatment activated autophagy by increased the ratio of LC3B-II/I and the protein levels of Beclin-1, decreased the levels of p62protein expression. Taken together, these findings demonstrated that puerarin could prevent the LPS/D-Gal-induced liver injury in mice, and its mechanisms might be associated with the increments of autophagy and suppression of apoptosis.

Study Type : Animal Study

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