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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Puerarin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of inflammation.

Abstract Source:

J Asian Nat Prod Res. 2018 Jan 11:1-18. Epub 2018 Jan 11. PMID: 29322879

Abstract Author(s):

Mao-Shan Yin, Yi-Chi Zhang, Shu-Hong Xu, Jing-Jing Liu, Xiao-Hui Sun, Chen Liang, Yan Wang, Jie Li, Fu-Wen Wang, Qing-Li Wang, Yan-Ling Mu

Article Affiliation:

Mao-Shan Yin

Abstract:

Diabetic cardiomyopathy (DCM) is one of the chief diabetes mellitus complications. Inflammation factors may be one reason for the damage from DM. The purpose of this research is to study the potential protective effects of puerarin on DM and the possible mechanisms of action related to NF-κB signal pathway. Following administration of puerarin to the disease model rat, several changes were observed including the changes of serum biochemical index, improved diastolic dysfunction, and enhanced endogenous antioxidant enzymes activities, further NF-κB signaling activation. Puerarin showed cardio-protective effects on DCM by inhibiting inflammation, and it might be a potential candidate for the treatment of DCM.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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