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Abstract Title:

Clinical assessment of a supplement of Pycnogenol® and L-arginine in Japanese patients with mild to moderate erectile dysfunction.

Abstract Source:

Phytother Res. 2012 Feb ;26(2):204-7. Epub 2011 May 27. PMID: 21618639

Abstract Author(s):

Hiromitsu Aoki, Junji Nagao, Taro Ueda, Jeffry M Strong, Frank Schonlau, Song Yu-Jing, Yan Lu, Shigeo Horie

Article Affiliation:

Central Laboratories, Kobayashi Pharmaceutical Co., Ltd., 4-4-10 Doshomachi, Chuo-ku, Osaka, Japan.

Abstract:

A double-blind parallel group comparison design clinical study was conducted in Japanese patients with mild to moderate erectile dysfunction to investigate the efficacy of a supplement containing Pycnogenol® and L-arginine. Subjects were instructed to take a supplement (Pycnogenol® 60 mg/day, L-arginine 690 mg/day and aspartic acid 552 mg/day) or an identical placebo for 8 weeks, and the results were assessed using the five-item erectile domain (IIEF-5) of the International Index of ErectileFunction. Additionally, blood biochemistry, urinalysis and salivary testosterone were measured. Eight weeks of supplement intake improved the total score of the IIEF-5. In particular, a marked improvement was observed in 'hardness of erection' and 'satisfaction with sexual intercourse'. A decreasein blood pressure, aspartate transaminase and γ-glutamyl transpeptidase (γ-GTP), and a slight increase in salivary testosterone were observed in the supplement group. No adverse reactions were observed during the study period. In conclusion, Pycnogenol® in combination with L-arginine as a dietarysupplement is effective and safe in Japanese patients with mild to moderate erectile dysfunction.

Study Type : Human Study

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