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Abstract Title:

The Effects of Pycnogenol® as Add-on Drug to Metformin Therapy in Diabetic Rats.

Abstract Source:

Phytother Res. 2016 Aug ;30(8):1354-61. Epub 2016 May 11. PMID: 27170051

Abstract Author(s):

Stanislava Jankyova, Dominika Rubintova, Lenka Janosikova, Peter Panek, Tatiana Foltanova, Eva Kralova

Article Affiliation:

Stanislava Jankyova

Abstract:

The progression of diabetes mellitus leads in time to the development of serious cardiovascular complications. Pycnogenol® (PYC) belongs to strong antioxidants that may interfere with different pathways playing an important role in diseases associated with oxidative stress. Metformin (MET), commonly used antidiabetic drug, has cardio-protective effects via activation of AMP kinase (AMPK). In our study, we examined the effects of PYC as add-on drug to metformin therapy in streptozotocin (STZ)-induced diabetic rats. Our results revealed that both used agents, PYC and MET, showed improvement of blood glucose levels, vascular reactivity, left ventricular hypertrophy, expression of AMPK, glucose transporter 4 (GLUT4) and calcium/calmodulin-dependent protein kinase II (CaMKII) in left ventricle of the hearts. However, the combination of these interventions has failed to possess higher efficacy. Copyright © 2016 John Wiley&Sons, Ltd.

Study Type : Animal Study

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Sayer Ji
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