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Abstract Title:

Improvement of common cold with Pycnogenol®: a Winter registry study.

Abstract Source:

Panminerva Med. 2014 ;56(4):301-8. PMID: 25424463

Abstract Author(s):

G Belcaro, H Shu, R Luzzi, M Dugall, E Ippolito, M R Cesarone, M Corsi, B Feragalli

Article Affiliation:

G Belcaro

Abstract:

AIM: This registry study aimed to evaluate the use of Pycnogenol® (pine bark extract), an anti-inflammatory, anti-oxidant and anti-edema natural compound, on symptoms of common cold. Main targets were the evaluation in otherwise healthy subjects of signs/symptoms, the reduction in days of disease, and the prevention of complications.

METHODS: All subjects used the"best management"for colds and one group added Pycnogenol® capsules (50 mg, bid/die) from day zero. The resulting registry groups were comparable. A total of 70 subjects used Pycnogenol® and 76 acted as controls.

RESULTS: The number of days with a perceived cold affecting the patients was reduced in the supplement group (3.1;0.4 days) in comparison with controls (4.2;0.2). Lost working days were significantly decreased in the supplement group (0.55;0.3 versus 0.67;0.3 in controls). The need to use any other compound (on demand basis; OTC products) to manage symptoms and the occurrence of any clinically significant complications were significantly lower in the Pycnogenol® group. The most frequent complications were the extension of the cold to a period longer than 4 days, a tracheal extension and a bronchial involvement. Pycnogenol® was significantly effective in reducing the number of complications. The daily evolution of the"pillar cold signs"indicates a significantly faster resolution in the supplement group. With supplementation the decrease in symptom scores appears to be significantly more important. Pycnogenol® supplementation appears to make regression faster for all symptoms in comparison with controls.

CONCLUSION: In this pilot registry, Pycnogenol® appears to decrease symptoms of cold and shorten its course also preventing some complications.

Study Type : Human Study

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Sayer Ji
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