Radiotherapy in breast cancer patients has been observed to suppress circulating CD34(+) cells by 15%. - GreenMedInfo Summary

Abstract Title:

The effect of local breast radiotherapy on circulating CD34(+) cells.

Abstract Source:

Radiother Oncol. 2011 Aug ;100(2):304-7. Epub 2011 Feb 11. PMID: 21316784

Abstract Author(s):

Nehad M Alajez, Wei Wang, Debashis Biswas, Amy Teh, Robert Sutherland, Melania Pintilie, Mark Minden, Hans Messner, Anthony Fyles, Mary Gospodarowicz, Armand Keating, Fei-Fei Liu

Article Affiliation:

Ontario Cancer Institute, Toronto, Canada.

Abstract:

The number of circulating CD34(+) (hematopoietic stem) cells (HSCs) was observed to decline by 15% in breast cancer patients after starting adjuvant radiation therapy, regardless of age or preceding chemotherapy. These data demonstrate that local radiation therapy can profoundly affect HSC homeostasis, which might have a myriad of important implications.

Article Published Date : Jul 31, 2011
Study Type : Human Study
Additional Links
Diseases : Breast Cancer: Conventional Treatment : CK(15) : AC(5)
Anti Therapeutic Actions : Radiotherapy : CK(417) : AC(75)
Adverse Pharmacological Actions : Immunotoxic : CK(484) : AC(118)

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Key Research Topics

Anti-Therapeutic Action

Radiotherapy

Adverse Pharmacological Actions

Immunotoxic

Disease

Breast Cancer: Conventional Treatment

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