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Article Publish Status: FREE
Abstract Title:

Incidence rate of type 2 diabetes is>50% lower in grassroots health cohort with median serum 25-hydroxyvitamin d of 41ng/ml than in nhanes cohort with median of 22ng/ml.

Abstract Source:

J Steroid Biochem Mol Biol. 2015 Jul 4. Epub 2015 Jul 4. PMID: 26151742

Abstract Author(s):

S L McDonnell, L L Baggerly, C B French, R P Heaney, E D Gorham, M F Holick, R Scragg, C F Garland

Article Affiliation:

S L McDonnell

Abstract:

Higher serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with lower risk of type 2 diabetes. This study compared incidence rates of type 2 diabetes among participants aged≥20 years in two U.S. cohorts with markedly different median 25(OH)D concentrations. The median 25(OH)D concentration in the Grassroots Health (GRH) cohort was 41ng/ml (N=4933) while in the 2005-6 National Health and Nutrition Examination Survey (NHANES) it was 22ng/ml (N=4078) (P<0.0001). The adjusted annual incidence rate of type 2 diabetes was 3.7 per 1000 population (95% confidence interval=1.9, 6.6) in the GRH cohort, compared to 9.3 per 1000 population (95% confidence interval=6.7, 12.6) in NHANES. In the NHANES cohort, the lowest 25(OH)D tertiles (<17, 17-24ng/ml) had higher odds of developing diabetes than the highest tertile (OR: 4.9, P=0.02 and 4.8, P=0.01 respectively), adjusting for covariates. Differences in demographics and methods may have limited comparability. Raising serum 25(OH)D may be a useful tool for reducing risk of diabetes in the population.

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