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Abstract Title:

Clinical and histological effect of a low glycaemic load diet in treatment of acne vulgaris in Korean patients: a randomized, controlled trial.

Abstract Source:

Acta Derm Venereol. 2012 May ;92(3):241-6. PMID: 22678562

Abstract Author(s):

Hyuck Hoon Kwon, Ji Young Yoon, Jong Soo Hong, Jae Yoon Jung, Mi Sun Park, Dae Hun Suh

Article Affiliation:

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.

Abstract:

Recent studies have suggested that dietary factors, specifically glycaemic load, may be involved in the pathogenesis of acne. The aim of this study was to determine the clinical and histological effects on acne lesions of a low glycaemic load diet. A total of 32 patients with mild to moderate acne were randomly assigned to either a low glycaemic load diet or a control group diet, and completed a 10-week, parallel dietary intervention trial. Results indicate successful lowering of the glycaemic load. Subjects within the low glycaemic group demonstrated significant clinical improvement in the number of both non-inflammatory and inflammatory acne lesions. Histopathological examination of skin samples revealed several characteristics, including reduced size of sebaceous glands, decreased inflammation, and reduced expression of sterol regulatory element-binding protein-1, and interleukin-8 in the low glycaemic load group. A reduction in glycaemic load of the diet for 10 weeks resulted in improvements in acne.

Study Type : Human Study

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Sayer Ji
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