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Abstract Title:

Anti-Remodeling Effects of Xanthohumol-Fortified Beer in Pulmonary Arterial Hypertension Mediated by ERK and AKT Inhibition.

Abstract Source:

Nutrients. 2019 Mar 9 ;11(3). Epub 2019 Mar 9. PMID: 30857304

Abstract Author(s):

Ana Filipa Silva, Gabriel Faria-Costa, Fábio Sousa-Nunes, Manuel Filipe Santos, Manuel João Ferreira-Pinto, Delfim Duarte, Ilda Rodrigues, João Tiago Guimarães, Adelino Leite-Moreira, Daniel Moreira-Gonçalves, Tiago Henriques-Coelho, Rita Negrão

Article Affiliation:

Ana Filipa Silva

Abstract:

Polyphenols present in some alcoholic beverages have been linked to beneficial effects in preventing cardiovascular diseases. Polyphenols found in beer with anti-proliferative and anti-cancer properties are appealing in the context of the quasi-malignant phenotype of pulmonary arterial hypertension (PAH). Our purpose was to evaluate if the chronic ingestion of a xanthohumol-fortified beer (FB) would be able to modulate the pathophysiology of experimental PAH. Male Wistar rats with monocrotaline (MCT)-induced PAH (60 mg/kg) were allowed to drink either xanthohumol-fortified beer (MCT + FB) or 5.2% ethanol (MCT + SHAM) for a period 4 weeks. At the end of the protocol, cardiopulmonary exercise testing and hemodynamic recordings were performed, followed by sample collection for further analysis. FB intake resulted in a significant attenuation of the pulmonary vascular remodeling in MCT + FB animals. This improvement was paralleled with the downregulation in expression of proteins responsible for proliferation (ERK1/2), cell viability (AKT), and apoptosis (BCL-XL). Moreover, MCT + FB animals presented improved right ventricle (RV) function and remodeling accompanied by VEGFR-2 pathway downregulation. The present study demonstrates that a regular consumption of xanthohumol through FB modulates major remodeling pathways activated in experimental PAH.

Study Type : Animal Study

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Sayer Ji
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