You’ll discover the most effective ways to prevent and beat cancer — from 131 of the world’s top experts — that you won’t hear about elsewhere.

Click Here for Exclusive Access!
n/a
Abstract Title:

Resveratrol promotes recovery of immune function of immunosuppressive mice by activating JNK/NF-κB pathway in splenic lymphocytes.

Abstract Source:

Can J Physiol Pharmacol. 2017 May 16:1-5. Epub 2017 May 16. PMID: 28511554

Abstract Author(s):

Xin Lai, Mei Cao, Xu Song, Renyong Jia, Yuanfeng Zou, Lixia Li, Xiaoxia Liang, Changliang He, Lizi Yin, Guizhou Yue, Gang Ye, Zhongqiong Yin

Article Affiliation:

Xin Lai

Abstract:

Resveratrol, a natural compound found in over 70 plants, is known to possess immunoregulatory effects and anti-inflammatory activity. It has been shown that resveratrol has regulatory effects on different signaling pathways in different diseases. However, few reports have evaluated the effects of resveratrol on reinforcing immunity recovery via activating nuclear factor-κB (NF-κB) pathway and Jun N-terminal kinases (JNK) pathway. The present study aimed to assess immune-enhancing activity and underlying mechanism of resveratrol in immunosuppressive mice. Previously, we reported that resveratrol could promote mouse spleen lymphocyte functions to recover the immunesystem effectively. In the present study, we show that resveratrol could upregulate the expressions of NF-κB, IκB kinase, JNK, and c-jun in splenic lymphocytes of immunosuppressive mice. Taken together, our results indicate that resveratrol could promote recovery of immunologic function in immunosuppressive mice by activating JNK/NF-κB pathway.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Immunomodulatory : CK(1287) : AC(358)

Print Options


Key Research Topics

You’ll discover the most effective ways to prevent and beat cancer — from 131 of the world’s top experts — that you won’t hear about elsewhere.

Click Here for Exclusive Access!

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2017 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.