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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

From immunotoxicity to carcinogenicity: the effects of carbamate pesticides on the immune system.

Abstract Source:

Environ Sci Pollut Res Int. 2016 May ;23(10):9448-58. Epub 2016 Mar 18. PMID: 26988364

Abstract Author(s):

Ines Dhouib, Manel Jallouli, Alya Annabi, Soumaya Marzouki, Najoua Gharbi, Saloua Elfazaa, Mohamed Montassar Lasram

Article Affiliation:

Ines Dhouib

Abstract:

The immune system can be the target of many chemicals, with potentially severe adverse effects on the host's health. In the literature, carbamate (CM) pesticides have been implicated in the increasing prevalence of diseases associated with alterations of the immune response, such as hypersensitivity reactions, some autoimmune diseases and cancers. CMs may initiate, facilitate, or exacerbate pathological immune processes, resulting in immunotoxicity by induction of mutations in genes coding for immunoregulatory factors and modifying immune tolerance. In the present study, direct immunotoxicity, endocrine disruption and inhibition of esterases activities have been introduced as the main mechanisms of CMs-induced immune dysregulation. Moreover, the evidence on the relationship between CM pesticide exposure, dysregulation of the immune system and predisposition to different types of cancers, allergies, autoimmune and infectious diseases is criticized. In addition, in this review, we will discuss the relationship between immunotoxicity and cancer, and the advances made toward understanding the basis of cancer immune evasion.

Study Type : Review

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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