Article Publish Status: FREE
Abstract Title:

Theobroma cacao: Review of the Extraction, Isolation, and Bioassay of Its Potential Anti-cancer Compounds.

Abstract Source:

Trop Life Sci Res. 2016 Feb ;27(1):21-42. PMID: 27019680

Abstract Author(s):

Zainal Baharum, Abdah Md Akim, Taufiq Yap Yun Hin, Roslida Abdul Hamid, Rosmin Kasran

Article Affiliation:

Zainal Baharum


Plants have been a good source of therapeutic agents for thousands of years; an impressive number of modern drugs used for treating human diseases are derived from natural sources. The Theobroma cacao tree, or cocoa, has recently garnered increasing attention and become the subject of research due to its antioxidant properties, which are related to potential anti-cancer effects. In the past few years, identifying and developing active compounds or extracts from the cocoa bean that might exert anti-cancer effects have become an important area of health- and biomedicine-related research. This review provides an updated overview of T. cacao in terms of its potential anti-cancer compounds and their extraction, in vitro bioassay, purification, and identification. This article also discusses the advantages and disadvantages of the techniques described and reviews the processes for future perspectives of analytical methods from the viewpoint of anti-cancer compound discovery.

Study Type : Review

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