Rhabdomyolysis and acute renal failure due to statin-fibrate combinations has been reported. - GreenMedInfo Summary

Abstract Title:

Rhabdomyolysis and acute renal failure after changing statin-fibrate combinations.

Abstract Source:

Cardiology. 2000 ;94(2):127-8. PMID: 11173785

Abstract Author(s):

J B Oldemeyer, R J Lund, M Koch, A J Meares, R Dunlay

Article Affiliation:

Department of Internal Medicine, Creighton University, Omaha, NE, USA.

Abstract:

Statin-fibrate combinations are commonly used to treat hyperlipidemia. These drugs have been previously reported to cause rhabdomyolysis with acute renal failure. Whether different statin-fibrate combinations have different risks for rhabdomyolysis is not known. We report a patient who developed rhabdomyolysis with acute renal failure promptly after switching from the combination of pravastatin and fenofibrate to simvastatin and gemfibrozil.

Article Published Date : Jan 01, 2000
Study Type : Human: Case Report
Additional Links
Diseases : Kidney Failure: Acute : CK(63) : AC(14), Rhabdomyolysis : CK(165) : AC(38), Statin-Induced Pathologies : CK(1848) : AC(369)
Problem Substances : Simvastatin : CK(791) : AC(165), Statin Drugs : CK(4587) : AC(559)

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Key Research Topics

Disease

Kidney Failure: Acute
Rhabdomyolysis
Statin-Induced Pathologies

Toxic Ingredients

Simvastatin
Statin Drugs

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