Abstract Title:

Rutin inhibits nitric oxide and tumor necrosis factor-alpha production in lipopolysaccharide and concanavalin-a stimulated macrophages.

Abstract Source:

Drug Metabol Drug Interact. 2007;22(4):263-78. PMID: 18447002

Abstract Author(s):

C Guruvayoorappan, Girija Kuttan

Abstract:

The effect of rutin, a flavonoid present in onions, apples, tea and red wine, on the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) was analyzed using in vitro as well as in vivo systems. The level of nitrite in lipopolysaccharide (LPS) stimulated BALB/c mice (88.21 microM) was significantly reduced in rutin treated animals (16.92 microM). The nitrite level in concanavalin-A (Con-A) treated control animals (77.15 microM) was also significantly reduced to 11.03 microM when the animals were pretreated with rutin. The drastically elevated levels of TNF-alpha in LPS stimulated animals (686.8 pg/ml) was lowered by pretreatment with rutin (182.4 pg/ml). Rutin also inhibited Con-A induced TNF-alpha production. Rutin inhibited nitrite production by activated macrophages in vitro (74.75 microM) to the normal level (16.13 microM) at a concentration of 5 microg/ml. In vitro L929 bioassay also showed inhibition of TNF-alpha production by rutin treatment.

Print Options


This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.