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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Salvianolic acid B-vitamin C synergy in cardiac differentiation from embryonic stem cells.

Abstract Source:

Biochem Biophys Res Commun. 2009 Oct 2;387(4):723-8. Epub 2009 Jul 28. PMID: 19643081

Abstract Author(s):

Sunny Sun-Kin Chan, Jyh-Hong Chen, Shiaw-Min Hwang, I-Ju Wang, Hui-Jing Li, Richard T Lee, Patrick C H Hsieh

Article Affiliation:

Institute of Clinical Medicine and Research Center for Clinical Medicine, National Cheng Kung University&Hospital, Tainan, Taiwan, ROC.

Abstract:

Inefficient cardiomyocyte differentiation limits the therapeutic use of embryonic stem (ES) cell-derived cardiomyocytes. While large collections of proprietary chemicals had been screened to improve ES cell differentiation into cardiomyocytes, the natural product library remained unexplored. Using a mouse ES cell line transfected with a cardiomyocyte-specific alpha-myosin heavy chain promoter-driven enhanced green fluorescent protein (EGFP) reporter, we screened 24 natural products with known cardioprotective actions. Salvianolic acid B (saB), while produced minimal effect on its own, concentration-dependently synergized with vitamin C in inducing cardiomyocyte differentiation, as demonstrated by an increase in EGFP(+) cells, beating area in embryoid bodies, and expression of cardiomyocyte maturity markers. This synergy is specific to cardiomyocyte differentiation, and is involved with collagen synthesis. The present study demonstrates the saB-vitamin C synergy in inducing ES cell differentiation into matured and functional cardiomyocytes, and this may lead to a practicable cocktail approach to generate ES cell-derived cardiomyocytes for cardiac stem cell therapy.

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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