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Abstract Title:

Serum bisphenol-A concentration and sex hormone levels in men.

Abstract Source:

Fertil Steril. 2013 May 4. Epub 2013 May 4. PMID: 23651625

Abstract Author(s):

Qin Zhou, Maohua Miao, Maomei Ran, Ling Ding, Lan Bai, Tingting Wu, Wei Yuan, Ersheng Gao, Jintao Wang, Guohong Li, De-Kun Li

Article Affiliation:

Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan, People's Republic of China.

Abstract:

OBJECTIVE: To evaluate the association between serum bisphenol-A (BPA) concentration and sex hormone levels in men. DESIGN: Cross-sectional study. SETTING: Not applicable. PATIENT(S): A total of 290 men with or without BPA exposure in the workplace. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Serum sex hormone levels. RESULT(S): After adjustment for potential confounders using linear regression, increasing serum BPA concentration was statistically significantly associated with [1] decreased androstenedione levels, [2] decreased free testosterone levels, [3] decreased free androgen index, and [4] increased sex hormone-binding globulin levels. Comparison of hormone levels between workers exposed and unexposed to BPA showed similar associations. CONCLUSION(S): Exposure to a high BPA level may impact sex hormone levels in men.

Study Type : Human Study
Additional Links
Problem Substances : Bisphenol A : CK(685) : AC(178)
Adverse Pharmacological Actions : Endocrine Disruptor: Testes : CK(1) : AC(1)

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Sayer Ji
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