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Abstract Title:

Protective effect of sesamol on the pulmonary inflammatory response and lung injury in endotoxemic rats.

Abstract Source:

Food Chem Toxicol. 2010 Jul ;48(7):1821-6. Epub 2010 Apr 14. PMID: 20398721

Abstract Author(s):

Pei-Yi Chu, Se-Ping Chien, Dur-Zong Hsu, Ming-Yie Liu

Article Affiliation:

Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan.

Abstract:

We investigated the effect of sesamol on systemic lipopolysaccharide (LPS)-induced lung inflammation in rats. Sesamol decreased lung edema and injury, significantly decreased LPS-induced cell counts, protein concentration, tumor necrosis factor (TNF)-alpha, and nitrite levels in bronchoalveolar lavage fluid, and decreased the TNF-alpha, nitrite, and inducible nitric oxide synthase protein expression in lung tissue. Further, sesamol significantly inhibited LPS-induced TNF-alpha, nitrite, inducible nitric oxide synthase expression, and nuclear factor-kappaB activation levels in primary alveolar macrophages. We hypothesize that sesamol attenuates systemic LPS-induced lung inflammation by inhibiting the alveolar macrophage inflammatory response in rats.

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Sayer Ji
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