GMI Home Log In Sign Up
Abstract Title:

Short-term study on the effects of rosemary on cognitive function in an elderly population.

Abstract Source:

J Med Food. 2012 Jan ;15(1):10-7. Epub 2011 Aug 30. PMID: 21877951

Abstract Author(s):

Andrew Pengelly, James Snow, Simon Y Mills, Andrew Scholey, Keith Wesnes, Leah Reeves Butler

Article Affiliation:

Herbal Medicine Department, Tai Sophia Institute, Laurel, Maryland 20723, USA. apengelly@tai.edu

Abstract:

Rosemary (Rosmarinus officinalis L.) has traditional reputations that justify investigation for a potential role in reducing widespread cognitive decline in the elderly. A randomized, placebo-controlled, double-blinded, repeated-measures crossover study was conducted to investigate possible acute effects of dried rosemary leaf powder on cognitive performance. Twenty-eight older adults (mean age, 75 years) were tested using the Cognitive Drug Research computerized assessment system 1, 2.5, 4, and 6 hours following a placebo and four different doses of rosemary. Doses were counterbalanced, and there was a 7-day washout between visits. There was a biphasic dose-dependent effect in measures of speed of memory: the lowest dose (750 mg) of rosemary had a statistically significant beneficial effect compared with placebo (P=.01), whereas the highest dose (6,000 mg) had a significant impairing effect (P<.01). There were significant deleterious effects on other measures of cognitive performance, although these were less consistent. Speed of memory is a potentially useful predictor of cognitive function during aging. The positive effect of the dose nearest normal culinary consumption points to the value of further work on effects of low doses over the longer term.

Study Type : Human Study

Print Options


Disqus

Login to Comment

Commenting is limited to Members only. If you are already a member, please login to post a comment. If you do not have a member account and would like to become a member, please click here to begin the process to become a member.