Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 250,000 with essential news, research & healthy tips, daily.

Easy Turmeric recipes + The Dark Side of Wheat

n/a
Abstract Title:

Role of p53 in silibinin-mediated inhibition of ultraviolet B radiation-induced DNA damage, inflammation and skin carcinogenesis.

Abstract Source:

Carcinogenesis. 2016 Oct 11. Epub 2016 Aug 11. PMID: 27729375

Abstract Author(s):

Cynthia M Rigby, Srirupa Roy, Gagan Deep, Ruth Guillermo-Lagae, Anil K Jain, Deepanshi Dhar, David J Orlicky, Chapla Agarwal, Rajesh Agarwal

Article Affiliation:

Cynthia M Rigby

Abstract:

Non-melanoma skin cancers (NMSC) are a growing problem given that solar UVB radiation exposure is increasing most likely due to depletion of the atmospheric ozone layer and lack of adequate sun protection. Better preventive methods are urgently required to reduce UV-caused photodamage and NMSC incidence. Earlier, we have reported that silibinin treatment activates p53 and reduces photodamage and NMSC, both in vitro and in vivo; but whether silibinin exerts its protective effects primarily through p53 remain unknown. To address this question, we generated p53 heterozygous (p53(+/-)) and p53 knockout (p53(-/-)) mice on SKH-1 hairless mouse background, and assessed silibinin efficacy in both short- and long-term UVB exposure experiments. In the chronic UVB exposed skin tumorigenesis study, compared to p53(+/+) mice, p53(+/-) mice developed skin tumors earlier and had higher tumor number, multiplicity and volume. Silibinin topical treatment significantly reduced the tumor number, multiplicity, and volume in p53(+/+) mice but silibinin' protective efficacy was significantly compromised in p53(+/-) mice. Additionally, silibinin treatment failed to inhibit precursor skin cancer lesions in p53(-/-) mice but improved the survival of the mice. In short term studies, silibinin application accelerated the removal of UVB-induced DNA damage in p53(+/+) mice while its efficacy was partially compromised in p53(-/-) mice. Interestingly, silibinin treatment also inhibited the UVB-induced inflammatory markers in skin tissue. These results further confirmed that absence of the p53 allele predisposes mice to photodamage and photocarcinogenesis, and established that silibinin mediates its protection against UVB-induced photodamage, inflammation and photocarcinogenesis partly through p53 activation.

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 250,000 with essential news, research & healthy tips, daily.

Easy Turmeric recipes + The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2017 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.