Sayer Ji
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Abstract Title:

Selenoprotein synthesis and side-effects of statins.

Abstract Source:

Lancet. 2004 Mar 13;363(9412):892-4. PMID: 15031036

Abstract Author(s):

Bernd Moosmann, Christian Behl

Article Affiliation:

Department of Pathobiochemistry, Johannes Gutenberg University, Medical School, Mainz, Germany.

Abstract:

Statins are possibly the most effective drugs for the prevention and treatment of hypercholesterolaemia and coronary heart disease. They are generally well tolerated, however, they do cause some unusual side-effects with potentially severe consequences, most prominently myopathy or rhabdomyolysis and polyneuropathy. We noted that the pattern of side-effects associated with statins resembles the pathology of selenium deficiency, and postulated that the mechanism lay in a well established, but often overlooked, biochemical pathway--the isopentenylation of selenocysteine-tRNA([Ser]Sec). A negative effect of statins on selenoprotein synthesis does seem to explain many of the enigmatic effects and side-effects of statins, in particular, statin-induced myopathy.

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Sayer Ji
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Easy Turmeric recipes + The Dark Side of Wheat

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