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Abstract Title:

ANCA-positive vasculitis associated with simvastatin/ezetimibe: expanding the spectrum of statin-induced autoimmunity?

Abstract Source:

Int J Rheum Dis. 2010 Aug ;13(3):e29-31. PMID: 20704607

Abstract Author(s):

Deepali Sen, Elliot D Rosenstein, Neil Kramer

Article Affiliation:

Department of Medicine, Saint Barnabas Medical Center, Livingston, NJ 07039, USA.

Abstract:

Although autoimmune syndromes such as systemic lupus erythematosus and dermatomyositis have been previously reported in association with statin use, vasculitis has not been well described. We present a patient with an antineutrophil cytoplasmic antibody-positive, predominantly cutaneous vasculitis, the temporal course of which was associated with simvastatin/ezetimibe use. The patient's serologic findings were consistent with drug-induced disease, with high titer antimyeloperoxidase, in addition to antinuclear and anti-Ro (SSA) antibodies. The patient demonstrated complete resolution of symptoms simply by withdrawing the drug.

Study Type : Human: Case Report

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Sayer Ji
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