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Abstract Title:

Xanthones with antiproliferative effects on prostate cancer cells from the stem bark of Garcinia xanthochymus.

Abstract Source:

Nat Prod Commun. 2012 Jan ;7(1):53-6. PMID: 22428244

Abstract Author(s):

Feng Ji, Zhanlin Lia, Gaofeng Liu, Shengli Niu, Nan Zhao, Xiaoqiu Liu, Huiming Hua

Article Affiliation:

Key Laborarory of Structure-Based Drug Design&Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China.

Abstract:

Investigations of the constituents of the stem barks of Garcinia xanthochymus have yielded two new compounds, garcinenones X (1) and Y (2), along with five known xanthones, 1,4,5,6-tetrahydroxy-7-(3-methylbut-2-enyl)xanthone (3), 1,4,6-trihydroxy-5-methoxy-7-(3-methylbut-2-enyl)xanthone (4), 1,4,5,6-tetrahydroxy-7,8-di(3-methylbut-2-enyl)xanthone (5), 1,3,5,6-tetrahydroxy-4,7,8-tri(3-methylbut-2-enyl)xanthone (6), and 1,5,6-trihydroxy-7,8-di(3-methylbut-2-enyl)-6',6'dimethylpyrano(2',3':3,4)xanthone (7). The structures of the compounds were determined by spectroscopic methods. The cell growth inhibitory activity of the isolated compounds against the PC-3 cell line was measured. Among them, compounds 2, 3, 5, and 6 exhibited significant inhibitory effects with IG50 values of 14.3, 15.5, 11.1, and 6.8 microM, respectively.

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