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Article Publish Status: FREE
Abstract Title:

Steroidogenic effects ofextract on the levels of steroidogenic enzymes in mouse Leydig cells.

Abstract Source:

Anim Cells Syst (Seoul). 2018 ;22(6):407-414. Epub 2018 Nov 8. PMID: 30533263

Abstract Author(s):

Hyun Joo Chung, Yoohun Noh, Min Su Kim, Ara Jang, Chae Eun Lee, Soon Chul Myung

Article Affiliation:

Hyun Joo Chung

Abstract:

In this study, we investigated the steroidogenic effect ofextract on mouse TM3 Leydig cells, which produce male hormones by increasing the levels of steroidogenic enzymes. Steroidogenic enzymes are involved in the production of testosterone in the testis. To date, the steroidogenic effect ofhas not been reported. Therefore, we examined the steroidogenic effects ofextract (TOE) on mouse Leydig cells in vitro. Traditionally, plants have been used for the treatment of various kinds of ailments. For many years, some medicinal plants have been used to regulate steroidogenesis or late-onset hypogonadism (LOH). In particular, plants belonging to the genus Taraxacum have anti-inflammatory, anti-nociceptive, anti-oxidant, and anti-cancer properties. In this study, we determined whether the TOE exerts steroidogenic effects by increasing the levels of enzymes associated with steroidogenesis, such as the steroidogenic acute regulatory protein (STAR), CYP11A1, and translocator protein (TSPO) in the mitochondria and CYP17A1 in the smooth endoplasmic reticulum, in mouse Leydig cells. Our results showed that the TOE significantly increased the mRNA and protein levels of steroidogenic enzymes, thereby increasing the testosterone levels in mouse Leydig cells. Thus, our results indicate that the TOE increases the levels of steroidogenic enzymes, and further studies are required to establish the potential of this plant in regulating steroidogenesis and improving LOH.

Study Type : In Vitro Study

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