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Article Publish Status: FREE
Abstract Title:

EFFECTS OF GINSENG AND ITS FOUR PURIFED GINSENOSIDES (Rb2, Re, Rg1, Rd) ON HUMAN PANCREATIC ISLETβ CELL IN VITRO.

Abstract Source:

Eur J Pharm Med Res. 2016 Jan ;3(1):110-119. PMID: 27547829

Abstract Author(s):

John Z Q Luo, Joseph W Kim, LuGuang Luo

Article Affiliation:

John Z Q Luo

Abstract:

Ginseng has attracted interest because of its potential therapeutic role in diabetes therapy. No direct evidence has shown the effects of ginseng and its components, ginsenosides, on human isletβ cell. In this study, we evaluated ginseng extract and ginsenosides (Rb2, Re, Rg1, Rd) on human pancreatic β cell function. The results provide direct evidence that ginseng extract promotes human pancreatic β cell function. Ginsenoside Rb2 increased islet β cell insulin release and promoted βcell migration. Ginsenoside Re had some impact on cell migration, but had no effect on islet function by evaluating insulin release. The other ginsenosides had no effect on insulin release and islet migration. To date, this is the first study that examines the impact of ginsenosides on human pancreatic islets in vitro.

Study Type : In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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