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Abstract Title:

The epidemiological profile of ASIA syndrome after HPV vaccination: an evaluation based on the Vaccine Adverse Event Reporting Systems.

Abstract Source:

Immunol Res. 2015 Feb ;61(1-2):90-6. PMID: 25381482

Abstract Author(s):

Paolo Pellegrino, Valentina Perrone, Marco Pozzi, Carla Carnovale, Cristiana Perrotta, Emilio Clementi, Sonia Radice

Article Affiliation:

Paolo Pellegrino

Abstract:

The term"ASIA-Autoimmune/inflammatory Syndrome Induced by Adjuvants"describes an umbrella of clinical conditions sharing similar signs or symptoms, including post-vaccination phenomena. No information is available on the epidemiology of the ASIA syndrome, especially following HPV vaccination. We carried out an analysis of the VAERS database to retrieve all cases of suspected ASIA syndrome according to the Shoenfeld and Agmon-Levin's guideline for the diagnosis. After causality assessment and case validation, 2,207 cases were considered probably or possibly related to vaccination. These represent the largest ASIA cohort ever reported and allowed us to estimate epidemiological and clinical characteristic of this syndrome. The commonest clinical manifestation observed were pyrexia (58%), myalgia (27%) and arthralgia or arthritis (19%), and the estimated reporting rate was of 3.6 cases per 100,000 doses of HPV vaccine distributed (95% CI 3.4-3.7). This study presents the first systematic estimation of ASIA incidence and expands the knowledge on this pathology. Further analyses are needed to identify genetic and non-genetic risk factors for ASIA syndrome.

Study Type : Human Study

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Sayer Ji
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