Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 250,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Consumption of soft drinks and juices and risk of liver and biliary tract cancers in a European cohort.

Abstract Source:

Eur J Nutr. 2014 Dec 21. Epub 2014 Dec 21. PMID: 25528243

Abstract Author(s):

Magdalena Stepien, Talita Duarte-Salles, Veronika Fedirko, Antonia Trichopoulou, Pagona Lagiou, Christina Bamia, Kim Overvad, Anne Tjønneland, Louise Hansen, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Gianluca Severi, Tilman Kühn, Rudolf Kaaks, Krasimira Aleksandrova, Heiner Boeing, Eleni Klinaki, Domenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Alessio Naccarati, H Bas Bueno-de-Mesquita, Petra H Peeters, Guri Skeie, Elisabete Weiderpass, Christine L Parr, José Ramón Quirós, Genevieve Buckland, Esther Molina-Montes, Pilar Amiano, Maria-Dolores Chirlaque, Eva Ardanaz, Emily Sonestedt, Ulrika Ericson, Maria Wennberg, Lena Maria Nilsson, Kay-Tee Khaw, Nick Wareham, Kathryn E Bradbury, Heather A Ward, Isabelle Romieu, Mazda Jenab

Article Affiliation:

Magdalena Stepien

Abstract:

PURPOSE: The aim of the study was to assess associations between intake of combined soft drinks (sugar sweetened and artificially sweetened) and fruit and vegetable juices and the risk of hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBC) and biliary tract cancers (GBTC) using data from the European Prospective Investigation into Cancer and Nutrition cohort of 477,206 participants from 10 European countries.

METHODS: After 11.4 years of follow-up, 191 HCC, 66 IHBC and 236 GBTC cases were identified. Hazard ratios and 95 % confidence intervals (HR; 95 % CI) were estimated with Cox regression models with multivariable adjustment (baseline total energy intake, alcohol consumption and intake pattern, body mass index, physical activity, level of educational attainment and self-reported diabetes status).

RESULTS: No risk associations were observed for IHBC or GBTC. Combined soft drinks consumption of>6 servings/week was positively associated with HCC risk: HR 1.83; 95 % CI 1.11-3.02, p trend = 0.01 versus non-consumers. In sub-group analyses available for 91 % of the cohort artificially sweetened soft drinks increased HCC risk by 6 % per 1 serving increment (HR 1.06, 95 % CI 1.03-1.09, n cases = 101); for sugar-sweetened soft drinks, this association wasnull (HR 1.00, 95 % CI 0.95-1.06; n cases = 127, p heterogeneity = 0.07). Juice consumption was not associated with HCC risk, except at very low intakes (<1 serving/week: HR 0.60; 95 % CI 0.38-0.95; p trend = 0.02 vs. non-consumers).

CONCLUSIONS: Daily intake of combined soft drinks is positively associated with HCC, but a differential association between sugar and artificially sweetened cannot be discounted. This study provides some insight into possible associations of HCC with sugary drinks intake. Further exploration in other settings is required.

Study Type : Human Study

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 250,000 with essential news, research & healthy tips, daily.

Depression: 21st Century Solutions + The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2018 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.